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Figure 2 | BMC Immunology

Figure 2

From: Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

Figure 2

Disease outcomes in arginase I-deficient BM chimeric mice. In A and B, cell composition of the BALF is shown from OVA and Aspergillus model experiments. Data are from 2–4 (OVA model) and 3–11 (Asp model) mice per group. In C, airway hyperresponsiveness is shown. Data are from 3–6 mice per group. In D, collagen content of the lung is shown. Data are from 4–6 mice per group. In E and F, quantification of Ki67-positive cells by immunohistochemistry in Asp and OVA model respectively, is shown. Data are from 2–6 mice/group. In C-F, two-way ANOVA demonstrated a statistically significant (P < 0.001) effect of treatment (allergen compared to saline), with no statistically significant effect of genotype or interaction (P > 0.05). In each panel, a representative experiment out of three performed is shown.

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BMC Immunology

ISSN: 1471-2172

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