Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity

Table 3 The significantly increased cytotoxicity of bone marrow MNCs obtained from mice pre-vaccinated 90 and 60 days prior to MNCs collection.

Group	p-value^a	p-value^b	p-value^c
1 × 90d*	0.014	0.031	0.011
2 × 90d*	0.016	0.023	0.002
3 × 90d*	0.001	0.002	<0.001
1 × 60d**	0.478	0.664	0.245
2 × 60d**	0.007	0.012	<0.001
3 × 60d**	0.001	0.003	<0.001

^a p-value: group compared to group vaccinated once 30 days before tumor challenge
^b p-value: group compared to group vaccinated twice: 30 and 15 days before tumor challenge
^c p-value: group compared to group vaccinated three times: 30, 15 and 7 days before tumor challenge
* vaccination started 90 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval
** vaccination started 60 days before the injection of viable tumor cells; the vaccine was applied once (1×), twice (2×) or three times (3×) in 15 days interval

ISSN: 1471-2172