BMC Immunology

Table 1 Comparison of the phenotypic characteristic of MDDC at three stages dependent on treatments

From: Immunoregulatory effects of AFP domains on monocyte-derived dendritic cell function

		Surface Marker Expression (%)
		CD14⁺	HLA-DR^high	CD80⁺	CD40⁺	CD83⁺
			/CD11c^high	/CD86^high
	Monocytes*	91.03 ± 0.75	42.70 ± 2.04	0.03 ± 0.03	22.83 ± 9.92	2.20 ± 0.70
Non Treated	imMDDC	5.80 ± 2.91	67.47 ± 3.94	1.33 ± 0.10	52.47 ± 14.98	15.83 ± 6.70
	mMDDC	5.17 ± 0.82	91.4 ± 3.12	92.57 ± 1.52	96.30 ± 0.75	80.97 ± 2.28
FL-AFP	imMDDC	1.30 ± 0.60	47.73 ± 4.45	2.47 ± 0.43	38.50 ± 7.30	10.33 ± 2.68
	mMDDC	1.47 ± 0.57	53.70 ± 3.94**	17.67 ± 2.35**	65.57 ± 0.30**	27.17 ± 3.94**
D1-AFP	imMDDC	2.40 ± 1.47	56.27 ± 2.50	3.50 ± 0.79	54.80 ± 11.47	12.30 ± 2.10
	mMDDC	1.87 ± 0.38	73.63 ± 4.76	65.47 ± 7.03	90.07 ± 3.66	59.27 ± 8.90
D2-AFP	imMDDC	1.07 ± 0.17	44.30 ± 2.04	6.37 ± 1.09	63.53 ± 10.02	17.10 ± 3.65
	mMDDC	2.40 ± 0.40	41.57 ± 6.20**	28.20 ± 4.59**	87.63 ± 5.51	34.70 ± 3.43**
D3-AFP	imMDDC	1.90 ± 0.53	48.27 ± 2.28	6.90 ± 1.65	66.30 ± 9.89	21.97 ± 5.88
	mMDDC	2.07 ± 0.09	43.80 ± 6.91**	27.47 ± 4.06**	85.27 ± 4.89	39.27 ± 6.21**

* ImMDDC is immature MDDC. mMDDC is mature MDDC. Generation of each cell is described in the "Methods".
**showed significant differences compare to non-treated (Tukey test, p < 0.05)

Back to article page

ISSN: 1471-2172

Contact us

General enquiries: journalsubmissions@springernature.com