Figure 4

The frequency of CD39⁺ Treg cells is correlated with HBV copy number and ALT level, but not HBeAg expression. (A) Correlations are shown between serum HBV loads and total Tregs (left panel) or CD39⁺ Tregs (middle panel) in AsCs, CAH and ACLF patients. The HBV copies in CD39high/int/low groups are summarized in CD4⁺ T cells expressing different levels of CD39 molecule (right panel). (B) Correlations are shown between serum ALT levels and total Tregs (left panel) or CD39⁺ Tregs (middle panel) in CAH and ACLF patients. The ALT levels in CD39high/int/low groups are summarized in CD4⁺ T cells expressing different levels of CD39 molecule (right panel). (C) Scatter plot summarizing flow cytometry data shows the percentage of CD4⁺ T cells expressing FoxP3 (left panel) or CD4⁺FoxP3⁺ T cells expressing CD39 (middle panel) in HBeAg(+)/(-) hepatitis B patients. The percentages of HBeAg(+) or (-) patients of the total patient number in CD39high/int/low groups are shown in the right panel. Mean values are indicated by the horizontal line. Bars represent mean ± SD. R is the correlation coefficient, and P-values are shown. * P < 0.05.