Figure 3

Analysis of the transcriptome data. The data were obtained from PBMCs following administration of CAWS to B6 and DBA/2 mice using Ingenuity Pathway Analysis software. This analysis suggested that among the three pathways of the complement system, the alternative pathway appears to be conspicuously activated. A network pathway is a graphical representation of the molecular relationships between molecules. Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line). All edges are supported by at least one reference from the literature, a textbook, or canonical information stored in the Ingenuity Knowledge Base. The green and red bars associated with each gene symbol indicate up- (red) and downregulated (green) mRNA expression at 2 w, 4 w, 8 w, or 9 w after CAWS administration in B6 (left; green bars) and DBA/2 mice (right; red bars). Upregulated and downregualted levels were measured as fold changes with respect to levels at 0 w.