Figure 6

Expression profiling of the microarray data for transcription factor genes following administration of CAWS to B6 and DBA/2 mice. (A) Mosaic tiles and hierarchical clustering of microarray data are shown. B6 and DBA/2 samples were clustered using a hierarchical clustering program (Spearman) to identify gene-to-gene relationships. Genes upregulated predominantly in DBA/2 mice following administration of CAWS are highlighted by colored and black arrows. (B) Intensity gradients indicate the mean value of the expression level (log2 ratio): blue (down-regulation) and crimson (upregulation) are shown compared to the average value at 0 w after CAWS administration (gray). (C) Scatter plots of highlighted genes in the log of signal intensity at 2 w (left panel) or 4 w (right panel) versus 0 w following CAWS administration in DBA/2 mice; data are plotted along the vertical and horizontal axes (arbitrary unit: a.u.), respectively.