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Table 2 Laboratory findings and serum biomarker levels of the RA patients in stable and AoDILD states

From: Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease

 

RA patients (n = 18)

 
 

Stable

AoDILD

P

White Blood Cell count(X1000/ml)

10.5 (3.8)

12.1 (3.4)

0.1578

Red Blood Cell count(X106/ml)

4.2 (0.5)

4.1 (0.6)

0.8506

Hemoglobin(g/dl)

12.6 (2.0)

12.3 (1.8)

0.6378

Hematocrit(%)

39.4 (5.5)

37.4 (5.3)

0.4703

Platelet(X1000/ml)

304.1 (121.2)

285.9 (108.4)

0.7064

Albumin(g/dl)

3.9 (0.4)

3.2 (0.6)

0.0052

Aspartate Aminotransferase(IU/l)

32.6 (39.8)

38.6 (27.2)

0.1167

Alanine Aminotransferase(IU/l)

28.0 (36.3)

26.4 (28.8)

0.8068

Lactate Dehydrogenase(IU/l)

224.7 (39.1)

371.8 (143.4)

0.0052

Alkaline Phosphatase(IU/l)

275.4 (129.1)

260.4 (93.3)

0.9721

γ-glutamyltransferase(IU/l)

33.5 (25.4)

110.9 (309.5)

0.1361

Creatinine(mg/dl)

0.6 (0.1)

0.7 (0.2)

0.3627

Blood Urea Nitrogen(mg/dl)

14.2 (2.8)

17.3 (4.6)

0.1005

C-reactive protein(mg/dl)

3.6 (3.6)

11.1 (9.3)

0.1094

KL-6(IU/ml)

447.9 (244.3)

829.2 (473.8)

0.0052

Surfactant Protein-D (SP-D)(U/ml)

74.1 (51.1)

169.3 (148.0)

0.0157

TIMP-1(pg/ml)

196945 (49413)

302152 (102113)

0.0071

TIMP-2(pg/ml)

117585 (23704)

99258 (16673)

0.0231

MMP-3(pg/ml)

910356 (732400)

451701 (312564)

0.0057

Osteopontin(pg/ml)

17095 (13228)

36200 (35682)

0.0198

Eotaxin2(pg/ml)

4482 (3387)

3308 (4017)

0.0108

IL-1RA(pg/ml)

187 (365)

401 (359)

0.0759

IL-2Rα(pg/ml)

3842 (2128)

8624 (6810)

0.0025

IL-6(pg/ml)

123 (260)

383 (852)

0.1119

MMP-1(pg/ml)

81755 (93582)

87509 (60314)

0.0582

MMP-8(pg/ml)

28379 (17114)

55764 (59399)

0.1841

MMP-3/MMP-1

20.66 (20.57)

12.83 (20.91)

0.0249

  1. RA: rheumatoid arthritis, AoDILD: Acute-onset diffuse interstitial lung disease. Average values of each group are shown. Standard deviations are shown in parenthesis. Differences were tested by Wilcoxon signed-rank test.