Differential gene expression by integrin β7+ and β7- memory T helper cells

BMC Immunology

Table 3 Surface expression of five gene products on β7⁺ versus β7^- CD4⁺ T cells

			Mean surface protein expression*
Gene	Fold difference: Transcript**	Fold difference: Surface protein***	CD45RA^- β7⁺ cells	CD45RA^- β7^- cells	CD45RA⁺ cells
LAIR1	+1.7	+2.5 (+1.6 to +3.9)	34.6	15.3	37.3
KLRB1	+1.7	+2.5 (+2.2 to +3.6)	26.1	10.7	1.1
KLRG1	+1.5	1.0 (-3.2 to +2.1)	17.7	15.6	9.1
NT5E	+1.3	+1.7 (+1.2 to +3.2)	20.3	11.7	6.8
SELL	-1.8	-1.8 (-2.1 to -1.5)	22.8	40.2	50.7

* Mean fluorescence intensity (MFI, in arbitrary units) was measured for 5–8 subjects.** As determined using DNA microarrays. *** Values represent mean (range) of the fold difference in MFI between CD45RA^- β7⁺ cells and CD45RA^- β7^- cells for all subjects. Positive fold difference values indicate higher expression on β7⁺ cells and negative fold difference values indicate higher expression on β7^- cells.

ISSN: 1471-2172