Figure 7
From: Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
DHT reduces thymus cellularity independently of estrogen receptors. 9-month-old male WT and DERKO mice were orchidectomized and treated for 4 weeks with E2 (0.05 μg/day) or DHT (45 μg/day), administered by s.c. silastic implants. Vehicle animals received empty implants. The E2-mediated reduction of thymus cellularity seen in WT mice, could not be detected in DERKO mice. Treatment with DHT resulted in a dramatic reduction of thymus cellularity independently of ER genotype. One-way ANOVA followed by Fisher's test was used to compare data from mice in different treatment groups. Results are presented as mean ± standard deviation. ***P < 0.001