Skip to main content
Figure 4 | BMC Immunology

Figure 4

From: Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation

Figure 4

p21WAF1/CIP1 over-expression prolongs allograft survival: A: p21 Injection of p21 sense plasmid DNA injected mice (set 2not empty vector plasmid DNA induces p21 mRNA expression in heart (h), liver (l), kidney (k) and spleen (s). B: Kaplan-Meyer survival graph for rat cardiac transplant recipients. Significant difference in the survival of allografts in p21WAF1/CIP1 transfected recipients compared to controls (* = p < 0.04) and p21WAF1/CIP1 together with CsA (* * = p < 0.005) can be seen. C: Effect of p21WAF1/CIP1 over-expression and CsA treatment on mRNA expression of IL-2 in lymphocytes and allografts. A significant decreased expression of IL-2 mRNA expression in lymphocytes and allografts compared to controls is shown (* = p < 0.01) and (* * = p < 0.001).

Back to article page