Table 4 The pooled AEs
AEs | Pooled rate (95% CI), % | No. of study | I2 (95% CI), % | P for I2 | Model | Egger's Test |
|---|---|---|---|---|---|---|
ICIs-based therapy | 31.8 (20.1–44.8) | 21 | 89.5 (85.4- 92.5) |  < 0.01 | Random effect | z = -0.1, p-value = 0.95 |
anti-CTLA-4 + anti-PD-(L)1 + radiotherapy | 29.3 (0.0–99.2) | 2 | 95.2 (85.8- 98.4) |  < 0.01 | Random effect | / |
anti-PD-(L)1 + TKIs | 21.7 (9.4–37.0) | 11 | 88.1 (80.7- 92.7) |  < 0.01 | Random effect | z = 0.0, p-value = 1.0 |
anti-PD-(L)1 + anti-VEGF + chemotherapy | 60.1 (7.6–100.0) | 2 | 93.0 (76.8- 97.9) |  < 0.01 | Random effect | / |
anti-PD-(L)1 + chemotherapy | 58.0 (17.8–93.1) | 3 | 91.3 (77.5- 96.6) |  < 0.01 | Random effect | z = 1.6, p-value = 0.12 |