Table 1 Demographics of patients with idiopathic inflammatory myopathy (IIM) and healthy control (HC)
Characteristics | IIM, ARS +  (n = 40) | IIM, MDA5 +  (n = 24) | P1 | HC (n = 60) | p2 |
|---|---|---|---|---|---|
Gender, n (%) | |||||
 Female | 31 (77.5) | 19 (79.2) | 0.14 | 48 (80) | 0.96 |
 Male | 9 (22.5) | 5 (4.2) |  | 12 (20) |  |
Age (years), median (IQR) | 58.0 (47.0–67.0) | 49.5 (43.4–58.8) | 0.07 | 37.0 (33.0–43.3) |  < 0.01 |
Organ involvement, n (%) | |||||
 Gottron's sign | 10 (25.0) | 15 (62.5) |  < 0.01 | NA |  |
 Skin rash | 13 (32.5) | 15 (62.5) | 0.02 | NA |  |
 Raynaud's phenomenon | 15 (37.5) | 3 (12.5) | 0.03 | NA |  |
 Periungual erythema | 14 (35.0) | 11 (45.8) | 0.39 | NA |  |
 Mechanic’s hand | 20 (50.0) | 14 (58.3) | 0.52 | NA |  |
 Muscle weakness | 20 (50.0) | 7 (29.2) | 0.10 | NA |  |
 Arthritis | 16 (40.0) | 9 (37.5) | 0.84 | NA |  |
 Interstitial lung disease | 18 (45.0) | 15 (62.5) | 0.18 | NA |  |
WBC count (× 10^3/μl), median (IQR) | 10.0 (8.4–15.7)a | 7.6 (5.6–11.3)b | 0.047 | NA |  |
 Neutrophil numbers (%) | 77.0 (68.8–85.6)a | 77.4 (70.8–86.8)b | 0.71 | NA |  |
 Lymphocyte numbers (%) | 10.6 (7.2–21.2)a | 15.0 (5.7–17.6)b | 0.70 | NA |  |
 NLR | 8 (3.3–11.8)a | 5.1 (4.0–15.8)b | 0.67 | NA |  |
Immunosuppressants, n (%) | 16 (40.0) | 8 (33.3) | 0.28 | NA | Â |
 Azathioprine | 5 (12.5) | 1 (4.2) | 0.27 | NA |  |
 Cyclophosphamide | 6 (15.0) | 0 (0) | NA | NA |  |
 Cyclosporin | 3 (7.5) | 3 (12.5) | 0.51 | NA |  |
 Methotrexate | 2 (5.0) | 6 (25) | 0.02 | NA |  |
 Mycophenolate | 3 (7.5) | 1 (4.2) | 0.59 | NA |  |
 Tacrolimus | 1 (2.5) | 0 (0) | NA | NA |  |
 Prednisolone ≥ 20 mg | 4 (10.0) | 2 (8.3) | 0.82 | NA |  |
Outcome, n (%) | |||||
 Alive | 39 (97.5) | 17 (77.3)c |  < 0.01 | NA |  |
 Death | 1 (2.5) | 5 (22.7)c |  | NA |  |