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Table 2 Examination of T cell subsets in peripheral blood from patients with idiopathic inflammatory myopathy (IIM) and healthy control (HC)

From: Immune cell profiles of idiopathic inflammatory myopathy patients expressed anti-aminoacyl tRNA synthetase or anti-melanoma differentiation-associated gene 5 autoantibodies

Cell subsets

ARS + 

(n = 40)

MDA5 + 

(n = 24)

P1

HC

(n = 60)

p2

CD3 T (%)

51.0 (33.2–65.0)

43.4 (35.7–53.6)

0.22

64.5 (56.6–71.3)

 < 0.001

 CD3 TN (%)

14.2 (10.6–22.3)

28.9 (20.8–35.5)

 < 0.01

32.3 (27.0–40.7)

 < 0.001

 CD3 TCM (%)

20.1 (13.5–30.2)

22.5 (17.2–28.3)

0.48

23.7 (20.2–27.4)

0.20

 CD3 TEM (%)

31.0 (23.7–40.3)

23.3 (16.9–27.7)

 < 0.01

27.2 (21.5–32.1)

 < 0.001

 CD3 TEMRA (%)

28.9 (15.4–42.2)

25.2 (16.7–35.3)

0.46

14.0 (7.4–20.5)

 < 0.001

CD4 T (%)

33.3 (22.5–40.5)

26.9 (21.0–29.9)

0.18

33.5 (27.6–40.0)

0.02

 CD4 TN (%)

16.7 (13.5–27.6)

27.3 (22.5–36.9)

 < 0.01

41.1 (30.2–48.4)

 < 0.001

 CD4 TCM (%)

25.0 (18.5–37.0)

28.2 (20.9–33.9)

0.60

29.2 (23.6–33.1)

0.85

 CD4 TEM (%)

31.4 (22.9–39.6)

20.1 (13.3–29.1)

 < 0.01

21.3 (16.8–28.6)

 < 0.001

 CD4 TEMRA (%)

16.6 (11.2–32.1)

18.9 (11.2–28.6)

0.77

8.8 (3.1–12.3)

 < 0.001

CD8 T (%)

26.0 (15.4–32.6)

17.8 (10.6–20.5)

 < 0.01

25.1 (20.5–29.1)

 < 0.001

 CD8 TN (%)

17.1 (10.9–27.5)

29.4 (22.7–36.5)

 < 0.01

42.5 (34.3–46.9)

 < 0.001

 CD8 TCM (%)

8.8 (4.4–14.4)

7.7 (4.5–11.4)

0.82

9.1 (6.8–11.3)

0.36

 CD8 TEM (%)

28.9 (21.4–40.4)

24.0 (18.6–29.9)

0.03

29.7 (23.8–35.3)

0.03

 CD8 TEMRA (%)

35.6 (23.4–47.9)

40.2 (24.7–45.3)

0.60

18.2 (13.1–26.4)

 < 0.001

  1. Data are presented as a median (interquartile range, IQR)
  2. Statistics: p1 value, calculated with Mann Whitney test between the MDA5 and ARS groups; p2 value, calculated with Kruskal–Wallis test among the MDA5, ARS, and HC groups
  3. Abbreviations: IIM Idiopathic inflammatory myopathy, ARS +  Anti-aminoacyl-tRNA synthetase autoantibody positive, MDA5 +  Anti-melanoma differentiation-associated gene 5 autoantibody positive, HC Healthy controls, TN Naïve T cells, TCM Central memory T cells, TEM Effector memory T cells, TEMRA Terminally differentiated effector memory T cells