Table 1 Cliniopathological parameters of low and high CYP27A1 expression group in TCGA-LUAD
Characteristic | Low expression of CYP27A1 | High expression of CYP27A1 | p |
|---|---|---|---|
n | 267 | 268 | |
T stage, n (%) | < 0.001 | ||
T1 | 63 (11.8%) | 112 (21.1%) | |
T2 | 161 (30.3%) | 128 (24.1%) | |
T3 | 32 (6%) | 17 (3.2%) | |
T4 | 11 (2.1%) | 8 (1.5%) | |
N stage, n (%) | 0.995 | ||
N0 | 172 (33.1%) | 176 (33.9%) | |
N1 | 48 (9.2%) | 47 (9.1%) | |
N2 | 37 (7.1%) | 37 (7.1%) | |
N3 | 1 (0.2%) | 1 (0.2%) | |
M stage, n (%) | 0.830 | ||
M0 | 189 (49%) | 172 (44.6%) | |
M1 | 12 (3.1%) | 13 (3.4%) | |
Pathologic stage, n (%) | 0.179 | ||
Stage I | 136 (25.8%) | 158 (30%) | |
Stage II | 70 (13.3%) | 53 (10.1%) | |
Stage III | 46 (8.7%) | 38 (7.2%) | |
Stage IV | 12 (2.3%) | 14 (2.7%) | |
Primary therapy outcome, n (%) | 0.106 | ||
PD | 44 (9.9%) | 27 (6.1%) | |
SD | 21 (4.7%) | 16 (3.6%) | |
PR | 2 (0.4%) | 4 (0.9%) | |
CR | 158 (35.4%) | 174 (39%) | |
Gender, n (%) | < 0.001 | ||
Female | 121 (22.6%) | 165 (30.8%) | |
Male | 146 (27.3%) | 103 (19.3%) | |
Age, n (%) | 0.008 | ||
< = 65 | 143 (27.7%) | 112 (21.7%) | |
> 65 | 115 (22.3%) | 146 (28.3%) | |
Smoker, n (%) | 0.005 | ||
No | 26 (5%) | 49 (9.4%) | |
Yes | 236 (45.3%) | 210 (40.3%) |