Table 2 Correlation analysis between CYP27A1 expression and OS analyzed by univariate and multivariate Cox regression

T stage

501

 T1

168

Reference

 T2

269

1.454 (1.019–2.075)

0.039

1.460 (0.924–2.307)

0.105

 T3&T4

64

3.030 (1.926–4.767)

 < 0.001

2.387 (1.282–4.443)

0.006

N stage

492

 N0

325

Reference

 N1

94

2.387 (1.692–3.366)

 < 0.001

1.492 (0.798–2.792)

0.210

 N2&N3

73

2.974 (2.037–4.343)

 < 0.001

1.266 (0.510–3.143)

0.611

M stage

360

 M0

335

Reference

 M1

25

2.111 (1.232–3.616)

0.007

2.446 (1.119–5.348)

0.025

Pathologic stage

496

 Stage I

270

Reference

 Stage II

119

2.469 (1.716–3.552)

 < 0.001

1.427 (0.725–2.808)

0.303

 Stage III

81

3.567 (2.438–5.218)

 < 0.001

2.467 (0.895–6.798)

0.081

 Stage IV

26

3.813 (2.197–6.618)

 < 0.001

Gender

504

 Female

270

Reference

 Male

234

1.060 (0.792–1.418)

0.694

CYP17A1

504

0.178 (0.063–0.502)

0.001

0.213 (0.072–0.632)

0.005