Skip to main content
Fig. 5 | BMC Immunology

Fig. 5

From: Dominant negative biologics normalise the tumour necrosis factor (TNF-α) induced angiogenesis which exploits the Mycobacterium tuberculosis dissemination

Fig. 5

Cytokine activity was measured in BAL fluid by ELISA. Levels for guinea pigs non-infected or infected receiving no treatment (Untreated), Standard TB treatment (RH), or with adjunctive Xpro-1595 (RH + Xpro-1595) were measured 28 days after the start of treatment. TNF activity decreased with TB treatment and was abrogated by the administration of adjunctive Xpro-1595. Samples were collected from n = 5 number of guinea pigs from each group, examined with triplicates to avoid false negative/false-positive results in the overall analysis. Results were plotted based on mean concentrations. M.tb infected, INH + RIF treatment groups were compared with Xpro-1595 + INH + RIF treatment group *** p < 0.005

Back to article page

BMC Immunology

ISSN: 1471-2172

Contact us