Table 2 Scoring parameters for histopathology at 4th and 8th week post infection M.tb infected and M.tb infected Xpro-1595 treated
Parameters | Different therapeutic groups of animals | |||||
|---|---|---|---|---|---|---|
M.tb infection 4th week | M.tb infection + Xpro-1595 treated 4th week | M.tb infection 8th week | M.tb infection + Xpro1595 treated 8th week | M.tb infection + DOTS | M.tb infection + DOTS + Xpro1595 treated 8th week | |
Infiltration factor (% mean) | 65% | 40% | 40% | 45% | 57.5% | 35 |
No. of lesions (mean) | 7.3 | 3.5 | 6 | 4.5 | 3 | 3 |
Granuloma/non granuloma | ++/+ | ++/+ | ++/++ | ++/++ | ++/+ | ++/+ |
Necrosis | +++ | ++ | ++ | + | ++ | + |
Cell population | Mø, Ly | Mø, Ly, Gaint cells | Mø, Ly | Mø, Ly | Mø, Ly | Mø, Ly |
AFB | 2+ | 2+ | 1+ | |||