Fig. 1

Sec1 regulated the progression of IBD in mice. (A) Gene expression of Fut2 in WT and the Sec1^−/− mice were determined by qRT-PCR. (B) Changes of body weight in Sec1^−/− and WT mice after induction of colitis. Data were expressed as the mean ± SEM. n = 15/14. **p < 0.01, ***p < 0.001. (C) Disease activity index (DAI) scores of Sec1^−/− and WT mice after induction of colitis. Data were expressed as the mean ± SEM. n = 15/14. **p < 0.01, ***p < 0.001. (D) Histopathological presentation of colonic tissue from Sec1^−/− and WT mice after induction of colitis. Tissue sections were stained with H&E and imaged at 100 × and 400 ×. Tissues were sampled from the distal colon of mice with DSS-induced colitis. Black arrows indicated areas that were imaged at a higher magnification (400 x). Scale bars were 100 μm (for 100 x) and 20 μm (for 400 x) respectively