Fig. 2
The frequency of CD8+ T-cell and CD4+ T-cell subsets between improved and non-improved patients before and after ALSS therapy. A The frequency of effector CD8+ T in non-improved patients was significantly lower after ALSS therapy. B The frequency of CD8+ TEM (C31, C36, C37) and CD8+ TEMRA (C32) in non-improved patients was significantly lower after ALSS therapy. C Heatmap of PD1, PD1, CTLA4, CD69, CD27, CD127, and Granulozyme B expression in CD4T+ and CD8T+ cell clusters. D The frequency of CD4+ TCM and CD4+ TEM in non-improved patients decreased significantly after ALSS and was lower than in improved patients. E The frequency of CD127+ TCM and CD4+ TEM in improved patients was higher than that before ALSS therapy. p < 0.05 was considered statistically significant, *p < 0.05. **p < 0.01. ALSS: artificial liver support system; EM: effector memory; EMRA: terminally differentiated effector memory; CM: central memory