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Fig. 5 | BMC Immunology

Fig. 5

From: Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation

Fig. 5

Pictorial presentation of the proposed hypothesis pertaining to apoptosis in the pathogenesis of pemphigus vulgaris. PV-IgG depletes desmoglein (Dsg)3 and causes actin filament reorganization, leading to acantholysis. FK506 blocks heat shock protein (HSP) 27 phosphorylation and prevents changes in Dsg3 depletion and actin filament reorganization

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BMC Immunology

ISSN: 1471-2172

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