Table 1 Association of PD1, PD-L1 and CD45RO + TILs with clinicopathological features of the disease
Variable | PD-1 | CD45RO | TC-PD-L1 | IC-PD-L1 | ||||
|---|---|---|---|---|---|---|---|---|
< 10% (%) | > 10% (%) | < 60% | > 60% | < 1% | > 1% | < 5% | > 5% | |
Age | 0.220 | 0.618 | 0.124 | 0.161 | ||||
< 58 | 26 (27.4) | 21 (22.1) | 26 (25.2) | 26 (25.2) | 24 (23.3) | 28 (27.2) | 17 (16.5) | 35 (34.0) |
> 58 | 20 (21.1) | 28 (29.5) | 23 (22.3) | 28 (27.3) | 16 (15.5) | 35 (34.0) | 24 (23.3) | 27 (26.2) |
Sex | 0.606 | 0.103 | 0.395 | 0.657 | ||||
Male | 35 (36.8) | 35 (36.8) | 32 (31.1) | 43 (41.7) | 31 (30.1) | 44 (42.7) | 31 (30.1) | 44 (42.7) |
Female | 11 (11.6) | 14 (14.7) | 17 (16.5) | 11 (10.7) | 9 (8.8) | 19 (18.4) | 10 (9.7) | 18 (17.5) |
Grade | 0.056 | 0.303 | 0.026 | 0.476 | ||||
I/II ii | 31 (34.8) | 42 (47.2) | 9 (9.3) | 9 (9.3) | 26 (26.8) | 53 (54.6) | 28 (28.9) | 51 (52.6) |
III | 11 (12.4) | 5 (5.6) | 35 (36.1) | 44 (45.4) | 11 (11.4) | 7 (7.2) | 8 (8.2) | 10 (10.3) |
T stage | 0.073 | 0.939 | 0.022 | 0.211 | ||||
T1/T2 | 10 (10.9) | 20 (21.7) | 15 (15.0) | 18 (18.0) | 7 (7.0) | 26 (26.0) | 10 (10.0) | 23 (23.0) |
T3/T4 | 33 (35.9) | 29 (31.5) | 31 (31.0) | 36 (36.0) | 30 (30.0) | 37 (37.0) | 29 (29.0) | 38 (38) |
Lymph node | 0.419 | 0.177 | 0.776 | 0.862 | ||||
Involved | 11 (12.1) | 16 (17.6) | 18 (18.2) | 14 (14.1) | 11 (11.1) | 21 (21.2) | 13 (13.1) | 19 (19.2) |
Free | 32 (35.2) | 32 (35.2) | 28 (28.3) | 39 (39.4) | 25 (25.3) | 42 (42.4) | 26 (26.3) | 41 (41.4) |
TNM stage | 0.144 | 0.880 | 0.089 | 0.177 | ||||
I + II | 9 (9.8) | 17 (18.5) | 13 (13.0) | 16 (16.0) | 7 (7.0) | 22 (22.0) | 8 (8.0) | 21 (21.0) |
III + IV | 34 (37.0) | 32 (34.8) | 33 (33.0) | 38 (38.0) | 30 (30.0) | 41 (41.0) | 31 (31.0) | 40 (40.0) |
Recurrence | 0.177 | 0.065 | 0.001 | 0.046 | ||||
Yes | 15 (15.8) | 10 (10.5) | 18 (17.5) | 11 (10.7) | 4 (3.9) | 25 (24.3) | 16 (15.6) | 13 (12.6) |
No | 31 (32.6) | 39 (41.1) | 31 (30.1) | 43 (41.7) | 36 (35.0) | 38 (36.8) | 25 (24.3) | 49 (47.5) |
Cancer death | 0.516 | 0.105 | 0.000 | 0.175 | ||||
Yes | 14 (14.7) | 12 (12.6) | 18 (17.5) | 12 (11.7) | 3 (2.9) | 27 (26.2) | 15 (14.6) | 15 (14.6) |
No | 32 (33.7) | 37 (38.9) | 31 (30.1) | 42 (40.8) | 37 (35.9) | 36 (35.0) | 26 (25.2) | 47 (45.6) |
Smoking | 0.621 | 0.272 | 0.033 | 0.832 | ||||
Yes | 25 (27.8) | 31 (34.4) | 26 (26.5) | 35 (35.7) | 28 (28.6) | 33 (33.7) | 23 (23.5) | 38 (38.8) |
No | 17 (18.9) | 17 (18.9) | 10 (20.4) | 17 (17.3) | 9 (9.2) | 28 (28.6) | 15 (15.3) | 22 (22.4) |
PD1 | 0.001 | 0.001 | 0.000 | |||||
< 10% | 29 (30.5) | 17 (17.9) | 26 (27.4) | 20 (21.1) | 27 (28.4) | 19 (20.0) | ||
> 10% | 14 (14.7) | 35 (36.8) | 12 (12.6) | 37 (38.9) | 11 (11.6) | 38 (40.0) | ||
CD45RO | 0.001 | 0.229 | 0.070 | |||||
< 60% | 29 (30.5) | 14 (14.7) | 22 (21.4) | 27 (26.2) | 24 (23.3) | 25 (24.3) | ||
> 60% | 17 (17.9) | 35 (36.8) | 18 (17.5) | 36 (35.0) | 17 (16.5) | 37 (35.9) | ||
TC-PD-L1 | 0.001 | 0.229 | 0.391 | |||||
< 1% | 26 (27.4) | 20 (21.1) | 22 (21.4) | 18 (17.5) | 18 (17.5) | 22 (21.4) | ||
> 1% | 20 (21.1) | 37 (38.9) | 27 (26.2) | 36 (35.0) | 23 (22.3) | 40 (38.8) | ||
IC-PD-L1 | 0.000 | 0.070 | 0.391 | |||||
< 5% | 27 (28.4) | 11 (11.6) | 24 (58.5) | 17 (16.5) | 18 (17.5) | 23 (22.3) | ||
> 5% | 19 (20.0) | 38 (40.0) | 25 (24.3) | 37 (35.9) | 22 (21.4) | 40 (38.8) | ||