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Table 2 Survival analysis for PD1, PD-L1, CD45RO + TILs and clinicopathological features

From: Negative prognostic behaviour of PD-L1 expression in tongue and larynx squamous cell carcinoma and its significant predictive power in combination with PD-1 expression on TILs

Variable

DFS

OS

β

S.E

HR

95% CI for HR

P-value

β

S.E

HR

95% CI for HR

P-value

Univariate Cox regression

 Age (Y)

 ≤ 58

  

1(Ref)

    

1 (Ref)

  

 > 58

0.067

0.372

1.070

0.516–2.217

0.856

0.122

0.366

1.130

0.551–2.316

0.739

 Sex

Male

  

1 (Ref)

    

1 (Ref)

  

Female

0.312

0.392

1.365

0.634–2.942

0.426

-0.031

0.408

0.970

0.436–2.157

0.940

 Origin

Tongue

  

1(Ref)

    

1 (Ref)

  

Larynx

-0.568

0.372

0.567

0.273–1.176

0.127

-0.342

0.377

0.711

0.339–1.489

0.365

 Histological Grade

I/II

  

1(Ref)

    

1(Ref)

  

III

0.483

0.467

1.621

0.649–4.047

0.301

0.573

0.473

1.774

0.702–4.484

0.226

 T stage

T3/T4

  

1(Ref)

    

1 (Ref)

  

T1/T2

-0.101

0.405

0.904

0.409–1.999

0.803

-0.284

0.402

0.753

0.342–1.657

0.481

 Lymph node status

Free

  

1 (Ref)

    

1 (Ref)

  

Involved

0.541

0.383

1.717

0.811–3.635

0.157

0.415

0.380

1.515

0.720–3.189

0.274

 PD1

 > 10%

  

1 (Ref)

    

1 (Ref)

  

 < 10%

0.537

0.409

1.711

0.768–3.812

0.189

0.294

0.404

1.342

0.608–2.962

0.466

 TC-PD-L1

 > 1%

  

1(Ref)

    

1 (Ref)

  

 < 1%

-1.596

0.540

0.203

0.070–0.583

0.003

-1.918

0.609

0.147

0.045–0.485

0.002

 IC-PD-L1

 > 5%

  

1 (Ref)

    

1 (Ref)

  

 < 5%

0.701

3.74

2.015

0.969–4.191

0.061

0.558

0.372

1.747

0.842–3.625

0.134

 TC-PDL1 intensity

2 + /3 + 

  

1 (Ref)

    

1 (Ref)

  

0/1 + 

-1.140

0.403

0.320

0.145–0.704

0.005

-1.134

0.399

0.322

0.147–0.704

0.005

 IC-PD-L1 intensity

2 + /3 + 

  

1 (Ref)

    

1 (Ref)

  

1 + 

0.866

0.404

2.378

1.078–5.247

0.032

0.639

0.418

1.894

0.835–4.299

0.127

 CD45RO

 > 60%

  

1 (Ref)

    

1 (Ref)

  

 < 60%

0.643

0.383

1.902

0.898–4.029

0.093

0.531

0.374

1.700

0.818–3.536

0.155

 Smoking

Yes

  

1 (Ref)

    

1 (Ref)

  

No

0.699

0.379

2.013

0.957–4.233

0.065

0.369

0.375

1.446

0.694–3.013

0.325

 TNM-stage

III/IV

  

1 (Ref)

    

1 (Ref)

  

I/II

-0.341

0.437

0.711

0.302–1.674

0.435

-0.549

0.437

0.578

0.245–1.361

0.210

Multivariate Cox regression

 PD1

 > 10%

  

1 (Ref)

    

1 (Ref)

  

 < 10%

1.164

0.458

3.202

1.305–7.860

0.011

0.982

0.444

2.671

1.120–6.370

0.027

 TC-PD-L1

 > 1%

  

1(Ref)

    

1(Ref)

  

 < 1%

-1.747

0.635

0.174

0.050–0.605

0.006

-1.665

0.634

0.189

0.055–0.655

0.009

  1. DFS disease-free survival, OS overall survival, S.E standard error, HR hazard ratio, 95% CI for HR 95% confidence interval for hazard ratio, TC-PD-L1 PD-L1 expression by tumor cells, IC-PD-L1 PD-L1 expression by immune cells
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BMC Immunology

ISSN: 1471-2172

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