Fig. 1

Study design. Eight CF reconstruction approaches (A3 – A10) were applied to eight AIRR-seq datasets, one mixed dataset, and three simulated datasets. In addition, we determined the number of unique junctions (A1) and subclones (A2) from each dataset. The mixed sample was generated from the experimental data. Our simulation approach used the experimental data as input to derive CFs. Results from all 10 approaches were analyzed. For the mixed and simulated samples, we also determined the number of shared clones and accuracy respectively