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Table 5 Storage stability of the Alginate/pCI-neo-UreH NPs in saline solution at 4 °C

From: Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

Time (h)

No treatment with nuclease

Nuclease treatment

Particle Size (nm)

PDI

Particle Size (nm)

PDI

0

384.24 ± 10.17

0.328 ± 0.05

384.24 ± 10.17

0.328 ± 0.05

24

395.10 ± 7.14

0.367 ± 0.04

387.91 ± 8.34

0.335 ± 0.43

48

404.31 ± 1.34

0.404 ± 0.007

389.42 ± 3.42

0.339 ± 0.37

72

421.14 ± 2.05

0.415 ± 0.024

389.39 ± 6.34

0.339 ± 0.86

  1. Notes: At 4 °C, the Alginate/pCI-neo-UreH NPs’ stability in saline solution was assessed. A particle size analyzer measured the particle size and PDI daily for 72 h (Anton Paar, Graz, Austria). The results demonstrated the absence of nanoparticle agglomeration