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Fig. 1 | BMC Immunology

Fig. 1

From: Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn’s disease correlates with disease activity

Fig. 1

The decrease in intestinal CD8+ γδ T cells in active CD patients was influenced by the severity of disease activity. (A) A full gating of flow cytometry plots of the enrolled cohorts. (B) Pooled data compared the absolute count of CD8+ γδ T cells (CD3 + TCR γδ + CD8+) in the intestinal mucosa of HCs and active CD patients. (C) Pooled data compared the frequency of CD8+ γδ T cells in the intestinal mucosa of HCs and active CD patients. (D) Pooled data compared the absolute count of CD8+ γδ T cells in the intestinal mucosa from HCs, mildly active CD patients, and moderately active CD patients. (E) Pooled data compared the frequency of CD8+ γδ T cells in the intestinal mucosa from HCs, mildly active CD patients, and moderately active CD patients. (F) Pooled data compared the CXCR3 expression on CD8+ γδ T cells in the intestinal mucosa of HCs and active CD patients. (G) Pooled data compared the CXCR3 expression on CD8+ γδ T cells in the intestinal mucosa from HCs, mildly active CD patients, and moderately active CD patients. HCs: healthy controls, CD: Crohn’s disease, CXCR3: chemokine receptor marker. Data are mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, p < 0.0001

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BMC Immunology

ISSN: 1471-2172

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