Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn’s disease correlates with disease activity

Table 2 Receiver operation characteristic curve parameters for active CD diagnosis

Parameters	AUC	P	95% CI	Cut-off value	Jordan index	sensitivity	specificity
HLA-DR⁺CD8⁺γδT	0.886	< 0.0001	0.7886–0.9823	> 21.90	0.6191	66.67%	95.24%
CD8⁺γδT ratio	0.819	0.0004	0.6847–0.9525	< 1.325	0.6667	66.67%	100%
CD8⁺γδT count	0.776	0.0022	0.6234–0.9276	< 0.08073	0.619	66.67%	95.24%
Granzyme B⁺CD8⁺γδT^C	0.846	0.0075	0.6544- 1.000	< 14.75	0.7091	90.91%	80%
Perforin⁺CD8⁺γδT^C	0.755	0.0486	0.5325–0.9766	< 8.015	0.6091	90.91%	70%

HLA-DR⁺ CD8⁺ γδT, CD8⁺ γδT ratio, and CD8⁺ γδT count refer to the ability of HLA-DR⁺ CD8⁺ γδT cell ratio, CD8⁺ γδT ratio, and CD8⁺ γδT count to distinguish between healthy controls and active CD cases. Granzyme B⁺ CD8⁺ γδT^C and Perforin⁺ CD8⁺ γδT^C refer to the ability of Granzyme B⁺ CD8⁺ γδT cell ratio and Perforin⁺ CD8⁺ γδT cell ratio to distinguish between mildly active CD cases and moderately-severely active CD cases.AUC, area under the curve; 95% CI, 95% confidence interval

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