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Table 1 Summary of respondent characteristics of the vial and PFS cohorts

From: Subcutaneous immunoglobulin replacement therapy in patients with immunodeficiencies – impact of drug packaging and administration method on patient reported outcomes

Respondent characteristics (n=220)

Vial cohort (A)

PFS cohort (B)

p values

Summary

n

Summary

n

A vs. B

Age (years), median [IQR]

57 [48, 66]

66

59 [49, 66]

120

0.34

Age at diagnosis (years), median [IQR]

46 [25, 59]

65

42 [25, 42]

118

0.99

Gender, n (%)

Female

39 (60.0%)

65

76 (63.9%)

119

0.61

Male

26 (40.0%)

43 (36.1%)

Bodyweight (kg), mean (± SD)

75.3 (± 17.2)

58

76.0 (± 17.5)

109

0.79

Underlying condition, n (%)

CVID

25 (47.2%)

53

37 (40.2%)

92

0.48

IgG Sub

13 (24.5%)

26 (28.3%)

DGS

2 (3.8%)

4 (4.4%)

SID

9 (17.0%)

10 (10.9%)

Othera

4 (7.6%)

15 (16.3%)

Years since diagnosis, n (%)

< 2 years

4 (6.2%)

65

10 (8.5%)

118

0.22

2–9 years

34 (52.3%)

46 (39.0%)

≥ 10 years

27 (41.5%)

62 (52.5%)

Time on IgG, n (%)

< 1 year

3 (4.6%)

66

5 (4.2%)

120

0.56

1–2 years

67 (10.6%)

21 (17.5%)

2–3 years

4 (6.1%)

17 (14.2%)

4–6 years

21 (31.8%)

18 (15.0%)

≥ 6 years

31 (47.0%)

59 (49.2%)

Current treatment experience, n (%)

< 2 years

8 (12.1%)

66

21 (17.8%)

118

0.26

2–9 years

44 (66.7%)

64 (54.2%)

≥ 10 years

14 (21.2%)

33 (28.0%)

Antibiotics before IgG, n (%)

No

44 (77.2%)

57

79 (74.5%)

106

0.71

Yes

13 (22.8%)

27 (25.5%)

Antibiotics since starting IgG, n (%)

No

24 (36.9%)

65

50 (43.9%)

114

0.37

Yes

41 (63.1%)

64 (56.1%)

  1. Categorical variables were analyzed using chi-squared tests, and continuous variables were analyzed using Analysis of Variance (ANOVA) post-hoc tests if found to be normally distributed, or Mann Whitney tests if otherwise. Significant p-values are highlighted in bold
  2. aOther indications are: X-linked agammaglobulinemia (vial, n=3; PFS, n=3), severe combined immunodeficiency (vial, n=0; PFS, n=4), specific antibody deficiency (vial, n=1; PFS, n=3), idiopathic autoimmune hemolytic Anemia (vial, n=1; PFS, n=0), autoimmune disease (vial, n=1; PFS, n=1), hypogammaglobulinemia (vial, n=1; PFS, n=1), chronic lymphocytic leukemia (vial, n=1; PFS, n=0), Waldenstrom macroglobulinemia (vial, n=1; PFS, n=0). CVID, common variable immune deficiency; DGS, DiGeorge syndrome; GHP, general health perception; GMH-2, global mental health 2; GPH-2, global physical health 2; IgG, immunoglobulin; IgG Sub, immunoglobulin subclass deficiency; IQR, interquartile range; kg, kilogram; PFS, pre-filled syringes; SCIg, subcutaneous immunoglobulin; SD, standard deviation; SID, secondary immunodeficiencies