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  1. Research article

    Chitosan gel vaccine protects against tumour growth in an intracaecal mouse model of cancer by modulating systemic immune responses

    Vaccination generating a robust memory population of CD8+ T cells may provide protection against cancer. However, immune therapies for cancer are influenced by the local tumour immune microenvironment. An infiltr...

    Andrew J. Highton, Adam Girardin, Georgia M. Bell, Sarah M. Hook and Roslyn A. Kemp

    BMC Immunology 2016 17:39

    Published on: 18 October 2016

  2. Research article

    A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains

    High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses of antigen specificity, clonality and diversity of T lymphocytes. Here, we developed a new TCR repertoire analysis meth...

    Kazutaka Kitaura, Tadasu Shini, Takaji Matsutani and Ryuji Suzuki

    BMC Immunology 2016 17:38

    Published on: 11 October 2016

  3. Research article

    Intranasal immunization with recombinant Toxoplasma gondii actin depolymerizing factor confers protective efficacy against toxoplasmosis in mice

    Toxoplasma gondii is an opportunistic protozoan closely associated with AIDS and vertical transmission. T. gondii actin depolymerizing factor (TgADF) plays an important role in actin c...

    Zhuanzhuan Liu, Litian Yin, Yaqing Li, Fei Yuan, Xiaofan Zhang, Jiazhi Ma, Hongmei Liu, Yanjuan Wang, Kuiyang Zheng and Jianping Cao

    BMC Immunology 2016 17:37

    Published on: 6 October 2016

  4. Research article

    Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer: comparison with polyp and cystitis

    Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign pros...

    Yanbo Liu, Wanguo Yang, Lijing Zhao, Zuowen Liang, Weigao Shen, Qinlong Hou, Zhenjiang Wang, Jing Jiang and Sun Ying

    BMC Immunology 2016 17:36

    Published on: 3 October 2016

  5. Research article

    IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients

    Cytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymp...

    Mahmoud Sadeghi, Imad Lahdou, Gerhard Opelz, Arianeb Mehrabi, Martin Zeier, Paul Schnitzler and Volker Daniel

    BMC Immunology 2016 17:35

    Published on: 3 October 2016

  6. Research article

    Treatment with Hizentra in patients with primary and secondary immunodeficiencies: a real-life, non-interventional trial

    Although Hizentra is indicated for immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies, phase III trials have focused on patients with primary immunodeficiencies. In th...

    J. F. Viallard, P. Agape, V. Barlogis, G. Cozon, C. Faure, F. Fouyssac, C. Gaud, M. P. Gourin, M. Hamidou, C. Hoarau, F. Husseini, M. Ojeda-Uribe, M. Pavic, I. Pellier, A. Perlat, N. Schleinitz…

    BMC Immunology 2016 17:34

    Published on: 29 September 2016

  7. Research article

    An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model

    Despite recent advances in early detection and improvements in chemotherapy for colon cancer, the patients still face poor prognosis of postoperative recurrence and metastasis, the median survival for patients...

    Huanyu Ju, Wenjing Xing, Jinfeng Yang, Yang Zheng, Xiuzhi Jia, Benning Zhang and Huan Ren

    BMC Immunology 2016 17:31

    Published on: 26 September 2016

  8. Research article

    Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells

    In the context of tumor immunology, tumor cells have been shown to overexpress CD47, an anti-phagocytic signal directed to macrophages to escape from phagocytosis by interacting with Signal Regulatory Protein ...

    Gizem Bener, Alex J. Félix, Cristina Sánchez de Diego, Isabel Pascual Fabregat, Carlos J. Ciudad and Véronique Noé

    BMC Immunology 2016 17:32

    Published on: 26 September 2016

  9. Research article

    Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

    Fetuin-A/AHSH is a novel hepatokine that acts as a vascular calcification inhibitor and as an endogenous TLR-4 ligand. Fetuin-A may act as a positive or negative acute phase protein (APP) in disease conditions...

    Sardar Sindhu, Nadeem Akhter, Steve Shenouda, Ajit Wilson and Rasheed Ahmad

    BMC Immunology 2016 17:33

    Published on: 26 September 2016

  10. Research article

    Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates

    Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced s...

    Yunier Rodríguez-Álvarez, Yanelys Morera-Díaz, Haydee Gerónimo-Pérez, Jorge Castro-Velazco, Rafael Martínez-Castillo, Pedro Puente-Pérez, Vladimir Besada-Pérez, Eugenio Hardy-Rando, Araceli Chico-Capote, Klaudia Martínez-Cordovez and Alicia Santos-Savio

    BMC Immunology 2016 17:30

    Published on: 26 September 2016

  11. Research article

    Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model

    Recently, the immunostimulatory roles of chemotherapeutics have been increasingly revealed, although bone marrow suppression is still a common toxicity of chemotherapy. While the numbers and ratios of differen...

    Yanhong Wu, Zhenling Deng, Huiru Wang, Wenbo Ma, Chunxia Zhou and Shuren Zhang

    BMC Immunology 2016 17:29

    Published on: 20 September 2016

  12. Research article

    Multi-layered Gag-specific immunodominant responses contribute to improved viral control in the CRF01_AE subtype of HIV-1-infected MSM subjects

    The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtyp...

    Fanming Jiang, Xiaoxu Han, Hui Zhang, Bin Zhao, Minghui An, Junjie Xu, Zhenxing Chu, Tao Dong and Hong Shang

    BMC Immunology 2016 17:28

    Published on: 30 August 2016

  13. Research article

    Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection

    The lung is exposed to airborne fungal spores, and fungi that colonize the oral cavity such as Candida albicans, but does not develop disease to opportunistic fungal pathogens unless the immune system is compromi...

    Sabarirajan Jayaraja, Azzeddine Dakhama, Bogeon Yun, Moumita Ghosh, HeeJung Lee, Elizabeth F. Redente, Charis L. Uhlson, Robert C. Murphy and Christina C. Leslie

    BMC Immunology 2016 17:27

    Published on: 8 August 2016

  14. Research article

    Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

    The mouse strain BALB/c deficient in IL-1 receptor antagonist protein (Il-1ra) develops spontaneous arthritis disease (SAD) while the strain DBA/1 IL1rn -/- with the same deficiency doe...

    Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart and Weikuan Gu

    BMC Immunology 2016 17:25

    Published on: 2 August 2016

  15. Research article

    Capparis Spinosa L. promotes anti-inflammatory response in vitro through the control of cytokine gene expression in human peripheral blood mononuclear cells

    Capparis Spinosa L. is an aromatic plant growing wild in dry regions around the Mediterranean basin. Capparis Spinosa was shown to possess several properties such as antioxidant, antif...

    Mouna Moutia, Khadija El Azhary, Anass Elouaddari, Abdellah Al Jahid, Jamal Jamal Eddine, Fouad Seghrouchni, Norddine Habti and Abdallah Badou

    BMC Immunology 2016 17:26

    Published on: 2 August 2016

  16. Research article

    Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins

    Major histocompatibility complex class I (MHCI) proteins present antigenic peptides for immune surveillance and play critical roles in nervous system development and plasticity. Most MHCI are transmembrane pro...

    Karla K. Frietze, Adlai L. Pappy, Jack W. Melson, Emily E. O’Driscoll, Carolyn M. Tyler, David H. Perlman and Lisa M. Boulanger

    BMC Immunology 2016 17:24

    Published on: 19 July 2016

  17. Research article

    Recombinant ArtinM activates mast cells

    Mast cells are hematopoietically derived cells that play a role in inflammatory processes such as allergy, as well as in the immune response against pathogens by the selective and rapid release of preformed an...

    Valéria Cintra Barbosa-Lorenzi, Nerry Tatiana Cecilio, Patricia Andressa de Almeida Buranello, Maria Cristina Pranchevicius, Maria Helena S. Goldman, Gabriela Pereira-da-Silva, Maria Cristina Roque-Barreira, Maria Célia Jamur and Constance Oliver

    BMC Immunology 2016 17:22

    Published on: 4 July 2016

  18. Research article

    Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells

    Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer’s patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-l...

    Kohichiro Tsukida, Takuya Takahashi, Hikaru Iida, Paulraj Kanmani, Yoshihito Suda, Tomonori Nochi, Shuichi Ohwada, Hisashi Aso, Sou Ohkawara, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena and Haruki Kitazawa

    BMC Immunology 2016 17:21

    Published on: 24 June 2016

  19. Research article

    Existence of Th22 in children and evaluation of IL-22 + CD4 + T, Th17, and other T cell effector subsets from healthy children compared to adults

    Children are prone to get infections, especially in the respiratory system and the gut mainly because their immune system is immature. T cells significantly contribute to the prevention of infections, and diff...

    Erxia Shen, Mengjie Wang, Hairui Xie, Ruqiong Zou, Qiwen Lin, Lili lai, Fujun Li, Zhimei Liang, Yanran Xu and Maohua Zhou

    BMC Immunology 2016 17:20

    Published on: 23 June 2016

  20. Research article

    Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications

    Inappropriate activation of T lymphocytes plays an important role in perinatal complications. However, data on T lymphocyte activation markers of preterm infants is scarce. We investigated the association betw...

    Florentina Sava, Gergely Toldi, András Treszl, Júlia Hajdú, Ágnes Harmath, Tivadar Tulassay and Barna Vásárhelyi

    BMC Immunology 2016 17:19

    Published on: 21 June 2016

  21. Research article

    Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice

    Humanized mouse models are an increasingly popular preclinical model to study the human immune response in a biological system. There are a variety of protocols to generate these mice, each differing in the st...

    Crystal Dykstra, Amanda J. Lee, Evan J. Lusty, Mira M. Shenouda, Mahsa Shafai, Fatemeh Vahedi, Marianne V. Chew, Stephen Collins and Ali A. Ashkar

    BMC Immunology 2016 17:18

    Published on: 16 June 2016

  22. Research article

    Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice

    Serglycin proteoglycans are essential for maturation of secretory granules and for the correct granular storage of cationic proteases in hematopoietic cells, e.g. mast cells. However, little is known about the...

    Ananya Roy, Osama Sawesi, Ulrika Pettersson, Anders Dagälv, Lena Kjellén, Anna Lundén and Magnus Åbrink

    BMC Immunology 2016 17:15

    Published on: 8 June 2016

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