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  1. Research article

    Association between IL-17 and IgA in the joints of patients with inflammatory arthropathies

    Hyperactive secretion and pathogenic effects of interleukin (IL)-17 and IgA have been detected in different arthropathies. Recent evidence has revealed that TH17 cytokines regulate mucosal IgA secretion. However,...

    Ricardo Javier Eliçabe, Juan Eduardo Silva, Mabel Noemí Dave, María Gabriela Lacoste, Héctor Tamashiro, Rodrigo Blas, Alicia Munarriz, Gabriel Adrián Rabinovich and María Silvia Di Genaro

    BMC Immunology 2017 18:8

    Published on: 6 February 2017

  2. Research article

    Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy

    While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify wh...

    Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama and Atsushi Kawakami

    BMC Immunology 2017 18:7

    Published on: 3 February 2017

  3. Research article

    Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determined by multiparametric single cell mass cytometry analysis

    Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies. Single cell immunophenotyping has historically been a...

    Elma Kadić, Raymond J. Moniz, Ying Huo, An Chi and Ilona Kariv

    BMC Immunology 2017 18:6

    Published on: 2 February 2017

  4. Research article

    Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome

    The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform...

    Kurt Hanevik, Einar Kristoffersen, Kristine Mørch, Kristin Paulsen Rye, Steinar Sørnes, Staffan Svärd, Øystein Bruserud and Nina Langeland

    BMC Immunology 2017 18:5

    Published on: 28 January 2017

  5. Research article

    Antigen presenting capacity of murine splenic myeloid cells

    The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised althoug...

    Ying-Ying Hey, Benjamin Quah and Helen C. O’Neill

    BMC Immunology 2017 18:4

    Published on: 11 January 2017

  6. Research Article

    Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

    Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included i...

    María Hernández-Trejo, Araceli Montoya-Estrada, Yessica Torres-Ramos, Aurora Espejel-Núñez, Alberto Guzmán-Grenfell, Rosa Morales-Hernández, Maricruz Tolentino-Dolores and Estibalitz Laresgoiti-Servitje

    BMC Immunology 2017 18:3

    Published on: 7 January 2017

  7. Research article

    Immune modulation of CD4+CD25+ regulatory T cells by zoledronic acid

    CD4+CD25+ regulatory T (Treg) cells suppress tumor immunity by inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer treatment. Zoledronic acid (ZA), a nitrogen-containing bisph...

    Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Jo-Lin Lo and Tsun-Mei Lin

    BMC Immunology 2016 17:45

    Published on: 25 November 2016

  8. Methodology article

    Optimization and evaluation of Luminex performance with supernatants of antigen-stimulated peripheral blood mononuclear cells

    The Luminex bead-based multiplex assay is useful for quantifying immune mediators such as cytokines and chemokines. Cross-comparisons of reagents for this technique from different suppliers have already been p...

    Mathieu Surenaud, Céline Manier, Laura Richert, Rodolphe Thiébaut, Yves Levy, Sophie Hue and Christine Lacabaratz

    BMC Immunology 2016 17:44

    Published on: 11 November 2016

  9. Research article

    The UT family of MHC class I loci unique to non-eutherian mammals has limited polymorphism and tissue specific patterns of expression in the opossum

    The Major Histocompatibility Complex (MHC) class I family of genes encode for molecules that have well-conserved structures, but have evolved to perform diverse functions. The availability of the gray, short-t...

    Katina V. Krasnec, Anthony T. Papenfuss and Robert D. Miller

    BMC Immunology 2016 17:43

    Published on: 8 November 2016

  10. Research article

    Lipoproteins attenuate TLR2 and TLR4 activation by bacteria and bacterial ligands with differences in affinity and kinetics

    The small intestine is a specialized compartment were close interactions take place between host, microbes, food antigens and dietary fatty acids. Dietary fats get absorbed by epithelial cells and processed in...

    Jeroen van Bergenhenegouwen, Aletta D. Kraneveld, Lieke Rutten, Johan Garssen, Arjan P. Vos and Anita Hartog

    BMC Immunology 2016 17:42

    Published on: 28 October 2016

  11. Research article

    Distinct phenotypic subpopulations of circulating CD4+CXCR5+ follicular helper T cells in children with active IgA vasculitis

    Circulating follicular helper T (Tfh) cells are a heterogeneous population of CD4+ helper T cells that promotes pathogenic immune responses in autoimmune diseases. In this study, we examined the status of differe...

    Deying Liu, Jinxiang Liu, Jinghua Wang, Congcong Liu, Sirui Yang and Yanfang Jiang

    BMC Immunology 2016 17:40

    Published on: 21 October 2016

  12. Research article

    Chitosan gel vaccine protects against tumour growth in an intracaecal mouse model of cancer by modulating systemic immune responses

    Vaccination generating a robust memory population of CD8+ T cells may provide protection against cancer. However, immune therapies for cancer are influenced by the local tumour immune microenvironment. An infiltr...

    Andrew J. Highton, Adam Girardin, Georgia M. Bell, Sarah M. Hook and Roslyn A. Kemp

    BMC Immunology 2016 17:39

    Published on: 18 October 2016

  13. Research article

    A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains

    High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses of antigen specificity, clonality and diversity of T lymphocytes. Here, we developed a new TCR repertoire analysis meth...

    Kazutaka Kitaura, Tadasu Shini, Takaji Matsutani and Ryuji Suzuki

    BMC Immunology 2016 17:38

    Published on: 11 October 2016

  14. Research article

    Intranasal immunization with recombinant Toxoplasma gondii actin depolymerizing factor confers protective efficacy against toxoplasmosis in mice

    Toxoplasma gondii is an opportunistic protozoan closely associated with AIDS and vertical transmission. T. gondii actin depolymerizing factor (TgADF) plays an important role in actin c...

    Zhuanzhuan Liu, Litian Yin, Yaqing Li, Fei Yuan, Xiaofan Zhang, Jiazhi Ma, Hongmei Liu, Yanjuan Wang, Kuiyang Zheng and Jianping Cao

    BMC Immunology 2016 17:37

    Published on: 6 October 2016

  15. Research article

    Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer: comparison with polyp and cystitis

    Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign pros...

    Yanbo Liu, Wanguo Yang, Lijing Zhao, Zuowen Liang, Weigao Shen, Qinlong Hou, Zhenjiang Wang, Jing Jiang and Sun Ying

    BMC Immunology 2016 17:36

    Published on: 3 October 2016

  16. Research article

    IL-23 plasma level is strongly associated with CMV status and reactivation of CMV in renal transplant recipients

    Cytomegalovirus seropositivity is an independent risk factor for atherosclerosis in patients with ESRD. Donor CMV seropositivity is associated with higher graft loss. Dendritic cells, macrophages and Th17 lymp...

    Mahmoud Sadeghi, Imad Lahdou, Gerhard Opelz, Arianeb Mehrabi, Martin Zeier, Paul Schnitzler and Volker Daniel

    BMC Immunology 2016 17:35

    Published on: 3 October 2016

  17. Research article

    Treatment with Hizentra in patients with primary and secondary immunodeficiencies: a real-life, non-interventional trial

    Although Hizentra is indicated for immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies, phase III trials have focused on patients with primary immunodeficiencies. In th...

    J. F. Viallard, P. Agape, V. Barlogis, G. Cozon, C. Faure, F. Fouyssac, C. Gaud, M. P. Gourin, M. Hamidou, C. Hoarau, F. Husseini, M. Ojeda-Uribe, M. Pavic, I. Pellier, A. Perlat, N. Schleinitz…

    BMC Immunology 2016 17:34

    Published on: 29 September 2016

  18. Research article

    An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model

    Despite recent advances in early detection and improvements in chemotherapy for colon cancer, the patients still face poor prognosis of postoperative recurrence and metastasis, the median survival for patients...

    Huanyu Ju, Wenjing Xing, Jinfeng Yang, Yang Zheng, Xiuzhi Jia, Benning Zhang and Huan Ren

    BMC Immunology 2016 17:31

    Published on: 26 September 2016

  19. Research article

    Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells

    In the context of tumor immunology, tumor cells have been shown to overexpress CD47, an anti-phagocytic signal directed to macrophages to escape from phagocytosis by interacting with Signal Regulatory Protein ...

    Gizem Bener, Alex J. Félix, Cristina Sánchez de Diego, Isabel Pascual Fabregat, Carlos J. Ciudad and Véronique Noé

    BMC Immunology 2016 17:32

    Published on: 26 September 2016

  20. Research article

    Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

    Fetuin-A/AHSH is a novel hepatokine that acts as a vascular calcification inhibitor and as an endogenous TLR-4 ligand. Fetuin-A may act as a positive or negative acute phase protein (APP) in disease conditions...

    Sardar Sindhu, Nadeem Akhter, Steve Shenouda, Ajit Wilson and Rasheed Ahmad

    BMC Immunology 2016 17:33

    Published on: 26 September 2016

  21. Research article

    Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates

    Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and ulcerative colitis; thus, inhibition of IL-15-induced s...

    Yunier Rodríguez-Álvarez, Yanelys Morera-Díaz, Haydee Gerónimo-Pérez, Jorge Castro-Velazco, Rafael Martínez-Castillo, Pedro Puente-Pérez, Vladimir Besada-Pérez, Eugenio Hardy-Rando, Araceli Chico-Capote, Klaudia Martínez-Cordovez and Alicia Santos-Savio

    BMC Immunology 2016 17:30

    Published on: 26 September 2016

  22. Research article

    Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model

    Recently, the immunostimulatory roles of chemotherapeutics have been increasingly revealed, although bone marrow suppression is still a common toxicity of chemotherapy. While the numbers and ratios of differen...

    Yanhong Wu, Zhenling Deng, Huiru Wang, Wenbo Ma, Chunxia Zhou and Shuren Zhang

    BMC Immunology 2016 17:29

    Published on: 20 September 2016

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