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  1. Research article

    The imbalance of Th17/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice

    Non-alcoholic fatty liver disease (NAFLD) is a common, chronic liver disease worldwide. Recent studies have shown that T helper (Th) 17 and regulatory T (Treg) cells play critical roles in various disorders of...

    Beihui He, Liyan Wu, Wei Xie, Yitong Shao, Jianping Jiang, Zhenzhong Zhao, Maoxiang Yan, Zhiyun Chen and Dawei Cui

    BMC Immunology 2017 18:33

    Published on: 24 June 2017

  2. Research

    Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes

    The RATE tool was recently developed to computationally infer the HLA restriction of given epitopes from immune response data of HLA typed subjects without additional cumbersome experimentation.

    Sinu Paul, Cecilia S. Lindestam Arlehamn, Veronique Schulten, Luise Westernberg, John Sidney, Bjoern Peters and Alessandro Sette

    BMC Immunology 2017 18(Suppl 1):20

    Published on: 21 June 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  3. Research

    A model of auto immune response

    In this work, we develop a theoretical model of an auto immune response. This is based on modifications of standard second messenger trigger models using both signalling pathways and diffusion and a macro leve...

    James K. Peterson, Alison M. Kesson and Nicholas J. C. King

    BMC Immunology 2017 18(Suppl 1):24

    Published on: 21 June 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  4. Methodology article

    Generation of populations of antigen-specific cytotoxic T cells using DCs transfected with DNA construct encoding HER2/neu tumor antigen epitopes

    Recent fundamental and clinical studies have confirmed the effectiveness of utilizing the potential of the immune system to remove tumor cells disseminated in a patient’s body. Cytotoxic T lymphocytes (CTLs) a...

    Maria Kuznetsova, Julia Lopatnikova, Julia Khantakova, Rinat Maksyutov, Amir Maksyutov and Sergey Sennikov

    BMC Immunology 2017 18:31

    Published on: 20 June 2017

  5. Research article

    Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands

    Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages ...

    Darrell Pilling, Elkin Galvis-Carvajal, Tejas R. Karhadkar, Nehemiah Cox and Richard H. Gomer

    BMC Immunology 2017 18:30

    Published on: 15 June 2017

  6. Research article

    Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells

    Humanized mice (hu mice) are based on the transplantation of hematopoietic stem and progenitor cells into immunodeficient mice and have become important pre-clinical models for biomedical research. However, da...

    Annette Audigé, Mary-Aude Rochat, Duo Li, Sandra Ivic, Audrey Fahrny, Christina K. S. Muller, Gustavo Gers-Huber, Renier Myburgh, Simon Bredl, Erika Schlaepfer, Alexandra U. Scherrer, Stefan P. Kuster and Roberto F. Speck

    BMC Immunology 2017 18:28

    Published on: 30 May 2017

  7. Research article

    The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection

    We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the ...

    Khamia Ryans, Yusuf Omosun, Danielle N. McKeithen, Tankya Simoneaux, Camilla C. Mills, Nathan Bowen, Francis O. Eko, Carolyn M. Black, Joseph U. Igietseme and Qing He

    BMC Immunology 2017 18:27

    Published on: 19 May 2017

  8. Research article

    The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

    T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional ...

    Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa and Hirokazu Murakami

    BMC Immunology 2017 18:26

    Published on: 16 May 2017

  9. Research article

    Recombinant Salmonella expressing SspH2-EscI fusion protein limits its colonization in mice

    Activation of inflammasome contributes to the clearance of intracellular bacteria. C-terminus of E. coli EscI protein can activate NLRC4 (NLR family, CARD domain containing-4) inflammasome in macrophages. The pur...

    Maozhi Hu, Weixin Zhao, Wei Gao, Wenhua Li, Chuang Meng, Qiuxiang Yan, Yuyang Wang, Xiaohui Zhou, Shizhong Geng, Zhiming Pan, Guiyou Cui and Xinan Jiao

    BMC Immunology 2017 18:21

    Published on: 3 May 2017

  10. Research article

    Poly I:C induces collective migration of HaCaT keratinocytes via IL-8

    Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound hea...

    Kazuhide Takada, Shihoko Komine-Aizawa, Naoko Hirohata, Quang Duy Trinh, Atsuyoshi Nishina, Hirokazu Kimura and Satoshi Hayakawa

    BMC Immunology 2017 18:19

    Published on: 24 April 2017

  11. Research article

    Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)

    To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE).

    Benjamin Chaigne, Carlo Chizzolini, Thomas Perneger, Marten Trendelenburg, Uyen Huynh-Do, Eric Dayer, Thomas Stoll, Johannes von Kempis and Camillo Ribi

    BMC Immunology 2017 18:17

    Published on: 28 March 2017

  12. Research article

    Validation of T-Track® CMV to assess the functionality of cytomegalovirus-reactive cell-mediated immunity in hemodialysis patients

    Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Pri...

    Bernhard Banas, Carsten A. Böger, Gerhard Lückhoff, Bernd Krüger, Sascha Barabas, Julia Batzilla, Mathias Schemmerer, Josef Köstler, Hanna Bendfeldt, Anne Rascle, Ralf Wagner, Ludwig Deml, Joachim Leicht and Bernhard K. Krämer

    BMC Immunology 2017 18:15

    Published on: 7 March 2017

  13. Methodology article

    An optimized IFN-γ ELISpot assay for the sensitive and standardized monitoring of CMV protein-reactive effector cells of cell-mediated immunity

    In healthy individuals, Cytomegalovirus (CMV) infection is efficiently controlled by CMV-specific cell-mediated immunity (CMI). Functional impairment of CMI in immunocompromized individuals however can lead to...

    Sascha Barabas, Theresa Spindler, Richard Kiener, Charlotte Tonar, Tamara Lugner, Julia Batzilla, Hanna Bendfeldt, Anne Rascle, Benedikt Asbach, Ralf Wagner and Ludwig Deml

    BMC Immunology 2017 18:14

    Published on: 7 March 2017

  14. Research article

    Immunogenicity and therapeutic effects of a Mycobacterium tuberculosis rv2190c DNA vaccine in mice

    Tuberculosis (TB) is a major global public health problem. New treatment methods on TB are urgently demanded. In this study, Mycobacterium tuberculosis (MTB) rv2190c DNA vaccine was prepared and its immunogenicit...

    Yan Liang, Xiaoyan Zhang, Xuejuan Bai, Li Xiao, Xiaomei Wang, Junxian Zhang, Yourong Yang, Jinying Song, Lan Wang and Xueqiong Wu

    BMC Immunology 2017 18:11

    Published on: 27 February 2017

  15. Research article

    Lipopolysaccharide mediates immuno-pathological alterations in young chicken liver through TLR4 signaling

    Lipopolysaccharide (LPS) induces acute liver injury and the complex mechanisms include the activation of toll like receptor 4 (TLR4) signaling pathway in many species. However, immuno-pathological changes duri...

    Xi-Yao Huang, Abdur Rahman Ansari, Hai-Bo Huang, Xing Zhao, Ning-Ya Li, Zhi-Jian Sun, Ke-Mei Peng, Juming Zhong and Hua-Zhen Liu

    BMC Immunology 2017 18:12

    Published on: 27 February 2017

  16. Research article

    In vitro evidence of efficacy and safety of a polymerized cat dander extract for allergen immunotherapy

    Allergy to cat epithelia is highly prevalent, being the major recommendation for allergy sufferers its avoidance. However, this is not always feasible. Allergen specific immunotherapy is therefore recommended ...

    María Morales, Mayte Gallego, Victor Iraola, Marta Taulés, Eliandre de Oliveira, Raquel Moya and Jerónimo Carnés

    BMC Immunology 2017 18:10

    Published on: 24 February 2017

  17. Research article

    Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells

    Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activa...

    Leon Bae, Julia K. Bohannon, Weihua Cui, Monika Vinish and Tracy Toliver-Kinsky

    BMC Immunology 2017 18:9

    Published on: 22 February 2017

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