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Fig. 2 | BMC Immunology

Fig. 2

From: Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study

Fig. 2

Signs of peripheral sensitization in TDI-sensitized mice. (A) Representative tracing of Ca2+ response (increased F340/F380) for a single neuron to pruritogens and agonists of itch receptors. (B) Substances induced intracellular Ca2+ increase in mouse sensory neuron showed a significant response to capsaicin, AITC, compound 48/80 and histamine in DRG neurons of TDI-sensitized group. Data are presented as the percentage of responsive cell per total DRG neuron (N = 8, * p < 0.05, ** p < 0.01, Fisher exact test). The relation of expression of IL31RA (C) and OSMR (D) mRNA in DRG of TDI-sensitized group comparing to control. Results are expressed as mean ± S.D. (N = 3, * p < 0.01, Independent t-test vs. control group)

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BMC Immunology

ISSN: 1471-2172

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