Table 2 Mendelian randomization analysis and sensitivity analysis
From: Causal relationship between immune cells and telomere length: mendelian randomization analysis
Exposure-Outcome | No. SNP | MR analysis | Heterogeneity | Pleiotropy | BWMR analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | P | Q | P | Intercept | P | OR(95%CI) | P | FDR | ||
Immune cells-Telomere length | ||||||||||
IgD+ %B cell | 17 | 0.994(0.989-1.000) | 0.037 | 17 | 0.402 | -0.002 | 0.152 | 0.994(0.988-1.000) | 0.040 | 0.050 |
CD20- %B cell | 18 | 0.993(0.987-0.999) | 0.016 | 17 | 0.452 | 0.000 | 0.826 | 0.991(0.984-0.999) | 0.026 | 0.043 |
IgD+ CD38- %lymphocyte | 20 | 0.995(0.991-1.000) | 0.039 | 18 | 0.544 | 0.001 | 0.198 | 0.996(0.988-1.005) | 0.398 | 0.398 |
CD25hi %CD4+ | 26 | 0.994(0.988-1.000) | 0.040 | 34 | 0.098 | -0.002 | 0.058 | 0.993(0.987-1.000) | 0.053 | 0.056 |
CD25hi CD45RA- CD4 not Treg %T cell | 32 | 0.996(0.993-1.000) | 0.044 | 31 | 0.447 | 0.000 | 0.816 | 0.996(0.992-1.000) | 0.053 | 0.056 |
CD33br HLA DR+ CD14dim %CD33br HLA DR+ | 22 | 0.994(0.990-0.999) | 0.020 | 20 | 0.530 | -0.001 | 0.182 | 0.994(0.989-0.999) | 0.016 | 0.038 |
Basophil %CD33dim HLA DR- CD66b- | 20 | 0.994(0.990-0.998) | 0.005 | 18 | 0.531 | 0.000 | 0.917 | 0.994(0.990-0.999) | 0.009 | 0.036 |
EM CD8br %CD8br | 24 | 1.004(1.000-1.007) | 0.027 | 18 | 0.775 | 0.000 | 0.861 | 1.004(1.000-1.008) | 0.035 | 0.050 |
CD45RA+ CD8br %CD8br | 24 | 0.997(0.994-1.000) | 0.019 | 17 | 0.825 | 0.000 | 0.949 | 0.996(0.993-1.000) | 0.033 | 0.050 |
Transitional AC | 31 | 0.991(0.984-0.997) | 0.006 | 43 | 0.055 | -0.002 | 0.126 | 0.992(0.984-1.000) | 0.040 | 0.050 |
DN (CD4-CD8-) NKT %T cell | 32 | 1.008(1.002-1.014) | 0.008 | 38 | 0.194 | 0.001 | 0.670 | 1.008(1.002-1.014) | 0.009 | 0.036 |
DN (CD4-CD8-) NKT %lymphocyte | 31 | 1.008(1.002-1.014) | 0.012 | 37 | 0.170 | -0.001 | 0.535 | 1.008(1.002-1.014) | 0.014 | 0.038 |
CD28+ CD45RA+ CD8br %CD8br | 42 | 1.002(1.000-1.003) | 0.003 | 54 | 0.079 | 0.000 | 0.584 | 1.002(1.001-1.003) | 0.006 | 0.036 |
CD25 on IgD+ CD24- | 25 | 0.997(0.994-0.999) | 0.020 | 30 | 0.177 | 0.000 | 0.967 | 0.996(0.993-0.999) | 0.021 | 0.038 |
CD62L on CD62L+ DC | 25 | 1.005(1.000-1.011) | 0.050 | 19 | 0.733 | -0.001 | 0.488 | 1.006(1.000-1.012) | 0.049 | 0.056 |
CD16-CD56 on HLA DR+ NK | 25 | 0.995(0.991-0.999) | 0.028 | 21 | 0.656 | -0.001 | 0.153 | 0.994(0.989-0.999) | 0.019 | 0.038 |
CD28 on resting Treg | 6 | 0.990(0.981-0.998) | 0.021 | 7 | 0.258 | 0.000 | 0.977 | 0.989(0.981-0.998) | 0.011 | 0.037 |
CD45 on NK | 26 | 1.007(1.001-1.013) | 0.028 | 31 | 0.180 | -0.001 | 0.521 | 1.009(1.002-1.017) | 0.017 | 0.038 |
CD25 on CD39+ CD4+ | 22 | 1.005(1.002-1.008) | 0.004 | 28 | 0.143 | 0.002 | 0.140 | 1.005(1.002-1.009) | 0.006 | 0.036 |
PDL-1 on CD14- CD16+ monocyte | 19 | 1.008(1.003-1.013) | 0.004 | 17 | 0.546 | 0.000 | 0.886 | 1.008(1.003-1.014) | 0.005 | 0.036 |
Telomere length-Immune cells | ||||||||||
EM CD8br %CD8br | 135 | 0.803(0.682-0.947) | 0.009 | 126 | 0.683 | 0.005 | 0.225 | 0.811(0.689-0.956) | 0.012 | 0.015 |
CD45RA+ CD8br %CD8br | 135 | 1.247(1.058-1.470) | 0.009 | 117 | 0.852 | -0.006 | 0.200 | 1.233(1.046-1.454) | 0.012 | 0.015 |
Transitional AC | 134 | 0.746(0.616-0.904) | 0.003 | 143 | 0.260 | 0.001 | 0.780 | 0.722(0.597-0.873) | 0.001 | 0.004 |
CD28+ CD45RA+ CD8br %CD8br | 135 | 1.169(1.006-1.359) | 0.042 | 144 | 0.266 | -0.006 | 0.105 | 1.155(0.992-1.345) | 0.064 | 0.064 |
CD25 on IgD+ CD24- | 134 | 1.291(1.060-1.571) | 0.011 | 142 | 0.283 | 0.003 | 0.524 | 1.324(1.082-1.620) | 0.006 | 0.015 |