Figure 7

Combination of IFN-β therapy and CXCR3 inhibition has an additive effect on delaying disease onset and attenuating disease severity in the mouse EAE model. IFN-β was administered at 1700 ng by daily intramuscular injection and SCH 546738 was orally twice daily at 30 mpk. The mouse EAE was conducted as described in Methods. Treatment with either IFN-β or SCH 546738 alone or the combination significantly delayed disease onset and attenuated disease severity (p < 0.05, two-tailed t test) at day 16, 17 and 19.