Figure 8From: A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejectionSCH 546738 delays graft rejection and in combination with cyclosporine, permits permanent engraftment in the rat cardiac allograft transplant model. SCH 546738 was administered orally twice daily at 1, 5 and 15 mpk. Cyclosporine was administered daily at 2.5 mpk. In the combination study, 5 mpk SCH 546738 and 2.5 mpk cyclosporine were administered. SCH 546738 significantly increased the mean survival time of the graft at 1 mpk (MST = 11 days; p < 0.05), 5 mpk (MST = 14 days; p < 0.05) and 15 mpk (MST = 14.9 days; p < 0.05) when compared with the vehicle control (MST = 6 days). Graft survival was analyzed using the log-rank test.Back to article page