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Figure 5 | BMC Immunology

Figure 5

From: Anti-idiotypic antibodies: a new approach in prion research

Figure 5

The proposed model of the 5D12-V5B2 complex obtained with molecular docking. (A) A ribbon diagram of the 5D12 and V5B2 variable regions illustrating the orientation of both binding partners with the CDR regions located at the molecular interface. (B) The amino-acid residues forming the putative 5D12 paratope. The residues from the VL and VH CDR regions are shown in yellow and orange, respectively. The only contact residue that lies outside of the CDR regions is coloured in green. (C) A semi-transparent depicition of the 5D12-V5B2 contact surface. The CDR loops from VL 5D12, VH 5D12, VL V5B2 and VH V5B2 are shown in yellow, orange, cyan and blue, respectively. Stick representation is used for all contact residues and wire representation of the backbone atoms is used for the remaining CDR residues. The contact residues that are not part of the CDR loops are coloured in green. The same representation, rotated for 180° around the vertical axis, is show in (D).

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