Figure 1
Primary and secondary immune responses to T cell-dependent antigen are intact in DPP IV null and inhibitor treated mice. Groups of C57BL/6, DPP IV null and C57BL/6 mice fed with chow containing inhibitor (n = 8) were immunized with NP-CGG in alum and bled various time thereafter and their sera analyzed for anti-NP λ (A), IgG1 (B) or anti-CGG IgG1 (C) titers by ELISA as described in Methods and Materials. The values shown for titers are units defined as EC50 of dilution factor × 100. (D) Represents the ratio of anti-NP λ bearing antibody titers obtained on NP2-BSA versus NP25-BSA coated plates. These data are representative of 3 independent experiments.