peptide responses are unaltered in wild type, DPP IV null and des-flurositagliptin treated animals. Proliferative response to MOG p35–55 of MOG primed T cells from wild-type (filled triangle), DPP IV null (inverted triangle) and des-flurositagliptin (filled diamond) treated animals (n = 4) from draining mesenteric lymph node (A) and spleen (B). Cells were isolated day 11 following immunization with MOG p35–55 in CFA. Cells were cultured with the indicated concentrations of MOG p35–55 for 72 h, and T cell proliferation in each culture was measured using [3H] thymidine incorporation assay. The cell proliferation is shown as counts per minute. Proliferation of unstimulated cells from MOG peptide immunized wild type, DPP IV null and wild type+ inhibitor treated mice was 2005 ± 553, 1678 ± 347 and 1876 ± 599 cpm respectively. These data are representative of 2 independent experiments.