Figure 5

In vivo CTL responses protocol in wild type, DPP IV and des-flurositagliptin treated mice. In vivo CD8 T cell responses were generated as outlined in the figure. The female mice were challenged with male cells and female cells differentially labeled with CSFE. Killing of male and female cells was assed by FACS analysis in wild type, DPP IV null and des-flurositagliptin treated animals.