Figure 3

Influence of anti-inflammatory drugs on rat dermal microvascular leakage induced by TM-N49 (5 μg), bradykinin (5 μg), PAF (5 μg) and histamine (5 μg). Ginkgolide (GG, 5 μg), cyproheptadine (CH, 5 μg), terfenadine (TF, 5 μg) or quinacrine (QC, 5 μg) were co-injected with TM-N49, bradykinin or histamine, respectively for 20 min, whereas PAF was only co-injected with GG. Skin reaction represented the area of Evan's blue extravasation. Data are displayed as a boxplot, which indicates the median, interquartile range, the largest and smallest values other than outliers (O) (defined as those which are more than 1.5 box lengths from the median) for 6 animals in each group. * P < 0.05 compared with the response to the corresponding uninhibited control animals.