Figure 4

Effects of TM-N49 on histamine release from colon, lung and tonsil mast cells in the presence or absence of exogenous calcium and magnesium. The values shown are mean ± SE for four to five separate experiments. Various concentrations of TM-N49 were incubated with cells for 15 min before termination of the reactions. * P < 0.05 compared with the response to the corresponding buffer alone group, ^†P < 0.05 compared with the response to the corresponding group in the absence of calcium and magnesium.