From: Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2
Compound (μg/ml) | Net histamine release (%) | ||||||
---|---|---|---|---|---|---|---|
 |  | Without metabolic inhibitors | With metabolic inhibitors | ||||
 |  | Lung | Colon | Tonsil | Lung | Colon | Tonsil |
TM-N49 | 3.0 | 9.3 ± 1.9 | 13.5 ± 3.0 | 8.0 ± 2.0 | 0.4 ± 0.4* | 0.4 ± 0.7* | 0.8 ± 0.6* |
 | 30 | 14.7 ± 4.7 | 29.6 ± 6.8 | 62.0 ± 8.5 | 1.6 ± 0.9* | 0.4 ± 1.4* | 49.3 ± 7.5 |
Anti-IgE | 10 | 17.3 ± 5.4 | 17.4 ± 5.1 | 11.1 ± 3.4 | 0.7 ± 1.7* | 0.1 ± 0.8* | 2.2 ± 1.5* |
CI | 0.5 | 24.4 ± 6.3 | 38.8 ± 4.6 | 37 ± 9.3 | 5.3 ± 5.5* | 2.1 ± 0.7* | 6.4 ± 2.9* |