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Table 3 Effect of TM-N49 on relative mast cell numbers in mouse peritoneum following injection.

From: Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2

TM-N49 (μg) Percentage of mast cells in total nucleated cells
  10 min 2 h 6 h 16 h
Saline 0.49(0.40–0.96) 0.45(0.31–1.30) 0.56(0.23–0.76) 0.85(0.29–1.88)
50 0.16(0.06–0.35)* 0.24(0.08–0.78)* 0.36(0.21–0.90) 0.05(0.03–0.11)*
5.0 0.76 (0.44–1.11) 1.05(0.60–1.77)* 0.67(0.29–1.76) 0.51 (0.22–1.36)
0.5 n.d n.d 0.61(0.39–1.00) 0.63 (0.27–1.10)
0.05 n.d n.d 0.90(0.39–2.67) 1.10 (0.47–1.31)
  1. Various doses of TM-N49 were injected into the peritoneum of mice for 10 min, 2 h, 6 h or 16 h. Also shown are the responses to normal saline control. Relative number of mast cells was defined as the percentage of mast cell in total nucleated cells. * P < 0.05 compared with the response to saline alone.