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Table 4 The influence of anti-inflammatory compounds on TM-N49 (5 μg) induced mast cell accumulation in mouse peritoneum

From: Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2

Compound injected Number of mast cells (× 103)
Saline   14.6 (6.1 – 23)
TM-N49   49.3 (20.3 – 65.9)
Ginkgolide B 5 mg·kg-1 26.2 (9.1 – 41)
Ginkgolide B 5 mg·kg-1 + TM-N49 19.6 (10 – 26)*
Cyproheptadine 2 mg·kg-1 6.2 (1.5 – 17.2)
Cyproheptadine 2 mg·kg-1 + TM-N49 21.9 (10.1 – 28.7)*
Terfenadine 2 mg·kg-1 11.0 (5.8 – 20)
Terfenadine 2 mg·kg-1 + TM-N49 9.5 (4.0 – 13.2)*
Quinacrine 10 mg·kg-1 11.5 (5.9 – 18.1)
Quinacrine 10 mg·kg-1 + TM-N49 59.7 (40.5 – 73.3)
  1. The values shown are medians (range) for six separate experiments. Compounds were injected into the mouse peritoneum for 6 h before peritoneal lavage fluid being collected. * P < 0.05 compared with the response to TM-N49 alone.