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Table 4 The influence of anti-inflammatory compounds on TM-N49 (5 μg) induced mast cell accumulation in mouse peritoneum

From: Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2

Compound injected

Number of mast cells (× 103)

Saline

 

14.6 (6.1 – 23)

TM-N49

 

49.3 (20.3 – 65.9)

Ginkgolide B

5 mg·kg-1

26.2 (9.1 – 41)

Ginkgolide B

5 mg·kg-1 + TM-N49

19.6 (10 – 26)*

Cyproheptadine

2 mg·kg-1

6.2 (1.5 – 17.2)

Cyproheptadine

2 mg·kg-1 + TM-N49

21.9 (10.1 – 28.7)*

Terfenadine

2 mg·kg-1

11.0 (5.8 – 20)

Terfenadine

2 mg·kg-1 + TM-N49

9.5 (4.0 – 13.2)*

Quinacrine

10 mg·kg-1

11.5 (5.9 – 18.1)

Quinacrine

10 mg·kg-1 + TM-N49

59.7 (40.5 – 73.3)

  1. The values shown are medians (range) for six separate experiments. Compounds were injected into the mouse peritoneum for 6 h before peritoneal lavage fluid being collected. * P < 0.05 compared with the response to TM-N49 alone.