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Table 5 The influence of blocking antibodies (Ab) against cell adhesion molecules on TM-N49 (5.0 μg) induced mast cell accumulation in mouse peritoneum

From: Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2

Compound injected

Number of mast cells (× 103)

Saline

 

14.6 (6.1 – 23)

TM-N49

 

49.3 (20.3 – 65.9)

L-selectin Ab

+ TM-N49

38.0 (19.1 – 68.8)

LFA-1 Ab

+ TM-N49

33.7 (18.9 – 55.2) *

CD18 Ab

+ TM-N49

25.1 (10.4 – 39.8)*

ICAM-1 Ab

+ TM-N49

14.8 (9.6 – 32.0)*

Hamster IgG1

+ TM-N49

39.8 (17.0 – 63.1)

Rat IgG2a

+ TM-N49

43.3 (19.3 – 58.0)

  1. The values shown are medians (range) for six separate experiments. Monoclonal antibodies (all at a dose of 1 mg·kg-1) against the adhesion molecules L-selectin, LFA-1, CD18 and ICAM-1 were intravenously injected, respectively for 30 min before intra-peritoneal injection of 5 μg of TM-N49 for 6 h. * P < 0.05 compared with the response to TM-N49 alone.
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BMC Immunology

ISSN: 1471-2172

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