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Table 5 The influence of blocking antibodies (Ab) against cell adhesion molecules on TM-N49 (5.0 μg) induced mast cell accumulation in mouse peritoneum

From: Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2

Compound injected Number of mast cells (× 103)
Saline   14.6 (6.1 – 23)
TM-N49   49.3 (20.3 – 65.9)
L-selectin Ab + TM-N49 38.0 (19.1 – 68.8)
LFA-1 Ab + TM-N49 33.7 (18.9 – 55.2) *
CD18 Ab + TM-N49 25.1 (10.4 – 39.8)*
ICAM-1 Ab + TM-N49 14.8 (9.6 – 32.0)*
Hamster IgG1 + TM-N49 39.8 (17.0 – 63.1)
Rat IgG2a + TM-N49 43.3 (19.3 – 58.0)
  1. The values shown are medians (range) for six separate experiments. Monoclonal antibodies (all at a dose of 1 mg·kg-1) against the adhesion molecules L-selectin, LFA-1, CD18 and ICAM-1 were intravenously injected, respectively for 30 min before intra-peritoneal injection of 5 μg of TM-N49 for 6 h. * P < 0.05 compared with the response to TM-N49 alone.