TY - JOUR AU - Ngai, Jacob AU - Inngjerdingen, Marit AU - Berge, Torunn AU - Taskén, Kjetil PY - 2009 DA - 2009/05/08 TI - Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation JO - BMC Immunology SP - 27 VL - 10 IS - 1 AB - TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 are less prone to subsequent TCR-activation. The heterotrimeric G proteins Gαq and Gαi2 have been implicated in CXCR4-signaling and we have recently also reported the possible involvement of Gαq in TCR-dependent activation of Lck (Ngai et al., Eur. J. Immunol., 2008, 38: 32083218). Here we examined the role of Gαq in migration and TCR activation. SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-10-27 DO - 10.1186/1471-2172-10-27 ID - Ngai2009 ER -