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Figure 7 | BMC Immunology

Figure 7

From: A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice

Figure 7

Proliferative capacity of mTOR+/kd T cells. (A) Proliferation of splenocytes after IL-2 stimulation. Spleen cells from mTOR+/+ and mTOR+/kd mice were stimulated with IL-2 in the presence or absence of rapamycin and proliferation was assessed by [3H] thymidine incorporation, as described in Methods. (B) Proliferation of spleen cells from mTOR+/+ and mTOR+/kd littermates in response to anti-CD3 with or without soluble anti-CD28 or IL-2 was measured as in (A). Data are expressed as % control. Results shown are representative of three experiments.

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BMC Immunology

ISSN: 1471-2172

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