Skip to main content
Figure 1 | BMC Immunology

Figure 1

From: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells

Figure 1

Extracellular Toll-like receptors gene expression in SARS-CoV infected human immature DCs by quantitative RT-PCR. Toll-like receptor (TLR)-1, TLR-2, TLR-4, TLR-5, TLR-6 and TLR-10 primarily expressed on cell surface. Their mRNA concentrations in adult (a) and CB (b) immature DCs were assayed at 3 h and 9 h after infection with SARS-CoV (MOI = 1). Mock infected cells were included as negative control. The concentrations were normalised to those of β-actin mRNA in the corresponding sample. In SARS-CoV infected adult DCs, significant upregulation of TLR-1 and TLR-2 at 3 h after infection was detected. The basal levels of extracellular TLRs gene expressions in CB DCs were high and no significant upregulation was detected after infection with SARS-CoV. Data are shown as mean ± SEM (adult n = 7; CB n = 5). The expression of TLR-10 was <1 copy per 104 β-actin genes (Data not shown).

Back to article page