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Figure 8 | BMC Immunology

Figure 8

From: The expression of the β-defensins hBD-2 and hBD-3 is differentially regulated by NF-κB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis

Figure 8

Activation of the EGFR is an upstream event in regulation of hBD-3 expression. OE21 cells were preincubated with a blocking EGFR antibody (10 μg/ml) for 1 h and then incubated with direct contact with 0.5 × 106 PMNs/ml and coincubation with 0.5 × 104 C. albican/ml in a transwell setting for additional 24 h. hBD gene expression was assessed by real time RT-PCR. Means ± s.d. of three independent experiments performed in triplicate are shown, * indicates p-value <0,05.

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