HUGO name | Nomenclature | Known agonists | Hydropathy similarity | Charge similarity | Putative ligands |
---|---|---|---|---|---|
NOD1 | NOD1 | iE-DAP | NALP5, NALP8 | NOD2, NALP5, NALP8 | n/a |
NOD2 | NOD2 | MDP, also modulates NALP1 activation | NALP7, NALP8 | NOD1, NALP7, NALP8 | n/a |
NLRC3 | NOD3 | Â | NALP3 | Â | no prediction |
NLRC4 | IPAF | Bacterial flagellin | TLR5, NALP14, CIITA | NALP14 | n/a |
NLRC5 | NOD4 | Â | NALP12, NALP13 | Â | no prediction |
NLRP1 | NALP1 | MDP | Â | Â | n/a |
NLRP2 | NALP2 | MDP | NALP3 | NALP3 | n/a |
NLRP3 | NALP3 | Bacterial RNA, MDP, R837, R848, CSs, etc. | NALP2, NOD3 | NALP2, NALP7 | n/a |
NLRP4 | NALP4 | Â | NALP14 | Â | no prediction |
NLRP5 | NALP5 | Â | NOD1, NALP8 | NOD1, NALP8 | small molecules |
NLRP6 | NALP6 | Â | TLR3 | TLR3 | RNA/DNA |
NLRP7 | NALP7 | Â | NOD2, NALP13 | NOD2, NALP3 | small molecules |
NLRP8 | NALP8 | Â | NOD1, NOD2, NALP5 | NOD1, NOD2, NALP5 | small molecules |
NLRP9 | NALP9 | Â | RI | RI | protein-like |
NLRP10 | NALP10 | Â | Â | Â | no prediction |
NLRP11 | NALP11 | Â | TLR7 | TLR3, TLR7 | RNA |
NLRP12 | NALP12 | Antagonizes IRAK-1 | NOD4 | Â | no prediction |
NLRP13 | NALP13 | Â | NOD4, NALP7 | Â | no prediction |
NLRP14 | NALP14 | Â | NALP4, IPAF | IPAF | flagellin |
NLRB1 | NAIP | Â | RI | TLR8 | no prediction |
NLRX1 | NOD5 | Â | Â | Â | no prediction |
NLRA | CIITA | ZXDC binds to LRR region | IPAF, TLR4, TLR5 | Â | protein-like |
 | RI | Ribonuclease | NALP9, NAIP | NALP9 | n/a |
 | TLR1 | triacyl lipopeptide (in complex with TLR2) |  |  | n/a |
 | TLR2 | triacyl-, diacyl-lipopeptides (in complex with TLR1, TLR6) |  |  | n/a |
 | TLR3 | dsRNA | NALP6 | NALP6, NALP11 | n/a |
 | TLR4 | LPS-loaded MD2 | CIITA |  | n/a |
 | TLR5 | Bacterial flagellin | IPAF, CIITA |  | n/a |
 | TLR6 | diacyl-lipopeptide (in complex with TLR2) |  |  | n/a |
 | TLR7 | ssRNA (HIV, SSV, influenza), imidazoquiniolines (e.g., R837), loxoribrine | TLR8, NALP11 | NALP11 | n/a |
 | TLR8 | ssRNA, imidazoquiniolines (e.g., R848) | TLR7 | NAIP | n/a |
 | TLR9 | Bacterial and viral CpG DNA motifs |  |  | n/a |
 | TLR10 |  |  |  | no prediction |