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Figure 1 | BMC Immunology

Figure 1

From: Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFβ gene variants

Figure 1

Regulatory T cell frequency is lower in PBMC of SLE patients than in controls (A) Lymphocytes gated according to forward and side scatter (FSC/SSC) from PMBC were screened by flow cytometry for the presence of CD4+CD25+ and CD4+CD25+CD45+ T cells. The FACS panel representing CD4+CD25+CD45RO+ PBMC is gated on CD4+ cells. Representative FACS stainings from an SLE patient and a healthy individual are shown, (B) box plot representing the frequency of CD4+CD25+ and CD4+CD25+CD45RO+ PBMC in patients (n = 76), relatives (n = 156) and controls (n = 193), showing that SLE patients have a significantly lower Treg frequency than healthy individuals and (C) Relative distribution of CD4+CD25+CD45+ T cell frequency in CD4+ T cells between male and female patients, relatives and controls, showing that females have a significantly lower frequency of CD4+CD25+CD45+ T cell frequency than males.

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