Figure 1

Schematic representation of FasL and its proline-rich region. A. FasL is a type II membrane protein. In its cytoplasmic N-Terminus, it contains a casein kinase I (CKI) substrate motif and a proline-rich domain (PRD). C-terminal to its transmembrane region (TM), FasL harbors cleavage sites for metalloproteases, a self-assembly (SA) region required for trimerization, several glycosylation sites and the C-terminal receptor binding TNF homology domain (THD). B. The amino acid sequences for the N-terminal cytoplasmic region of human and murine FasL are displayed to highlight the unique proline-rich domain spanning about 30 amino acids.